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Veloxin

 (Moxifloxacin Chloride)

The WHO-Recommended Drug for Multi-Drug Resistant TB

Veloxin (Moxifloxacin) is a fluroquinolone, i.e., a broad-spectrum antibiotic that treats a variety of bacterial-resistant infections. It is particularly recommended by the American Thoracic Society and Infectious Disease Society for the treatment of multi-drug resistant tuberculosis (MDR-TB).

Veloxin has a high clinical success rate. It has excellent tissue penetration and is active against both gram-positive and gram-negative bacteria. It inhibits bacterial cell replication by inhibiting DNA gyrase (topoisomerase II) and topoisomerase IV – types of enzymes crucial for bacterial DNA replication.

Dosage

Take Veloxin by mouth with or without food as directed by your pharmacist. The dosage and length of treatment are based on your medical condition and response to treatment.

  • MDR-TB –once a day for 6 months (intensive phase) and 12-18 months (continuation phase)
  • AECB – once a day for 5 consecutive days
  • CAP – once a day for 10 consecutive days
  • ABS – once a day for 7 consecutive days

Drink plenty of fluids while taking this drug unless your doctor tells you otherwise.

For the best effect, take this antibiotic at evenly spaced times. To help you remember, take this medication at the same time(s) every day.

Side Effects

Veloxin is well-tolerated, however the patient may feel:

  • Nausea
  • Diarrhea
  • Dizziness & lightheadedness
  • Headache
  • Weakness
  • Sleeplessness

If any of these effects persist or worsen, tell your doctor or pharmacist immediately.

If any of the following effects occur, contact your doctor right away:

  • Unusual bruising/bleeding – it indicates infection such as new/persistent fever or persistent sore throat
  • Changes in the amount of urine – it may indicate kidney problems
  • Yellowing of skin/eyes and urine and persistent abdominal pain – it indicates liver problems

Get medical help right away if you have any of the following serious side effects

  • Fast/irregular heartbeat
  • Severe dizziness
  • Fainting

 

Precautions

Veloxin is an antibiotic, it treats only bacterial infections. Do not use it to treat viral infections such as common cold and flu. Unnecessary use or overuse of any antibiotic can lead to its resistance and reduced effectiveness.

If you are allergic to other quinolone antibiotics (such as ciprofloxacin, levofloxacin), inform your doctor before taking veloxin. Veloxin may cause allergic reactions or other problems.

Veloxin may also affect the heart rhythm (QT prolongation). QT prolongation can rarely cause serious (rarely fatal) fast/irregular heartbeat and other symptoms (such as severe dizziness, fainting) that need medical attention right away.

Indications

  • MDR-TB
  • Acute bacterial sinusitis (ABS)
  • Acute exacerbation of chronic bronchitis (AECB)
  • Community acquire pneumonia (CAP)