Ritufen 250 mg
Ritufen contains the synthetic allylamine antifungal compound terbinafine hydrochloride.
Mode of Action
Ritufen (Terbinafine) has a fungicidal effect by inhibiting the enzyme squalene monooxygenase which is involved in the synthesis of sterol in fungi. This inhibits fungal sterol biosynthesis by decreasing ergosterol levels. Fungal membranes are not able to grow because ergosterol is one of the main components of the fungal cell membrane. Additionally, squalene accumulates which weakens the cell membrane. Orally, the drug is very effective due to its ability to concentrate within the nails.
Indication and Uses
Ritufen Tablets are contraindicated in individuals with a history of allergic reaction to oral terbinafine because of the risk of anaphylaxis.
Dosage & Instructions
Fingernail onychomycosis: One 250 mg tablet, once daily for 6 weeks.
Toenail onychomycosis: One 250 mg tablet, once daily for 12 weeks.
Tinea Pedis: one 250 mg tablet , once daily or divided q12hr for 2-6 weeks
Tinea Corporis, Tinea Cruris : one 250 mg tablet , once daily or divided q12hr for 2-4 weeks