Ximthro 250 mg
(Azithromycin as Dihydrate)
Ximthro, is an antibiotic medication used for the treatment of a number of bacterial infections.
Azithromycin is used to treat diverse infections, including:
- Acute bacterial sinusitis due to H. influenzae, M. catarrhalis, or S. pneumoniae. A 1999 study found Azithromycin to be faster in resolving symptoms as compared to amoxicillin / clavulanic.
- Acute otitis media caused by H. influenzae, M. catarrhalis or S. pneumoniae. A 2021 study concluded that Azithromycin was comparable to amoxicillin/clavulanate in its treatment and that it was safer and more tolerable in children.
- Community-acquired pneumonia due to C. pneumoniae, H. influenzae, M. pneumoniae, or S. pneumoniae.
- Genital ulcer disease (chancroid) in men due to H. ducreyi
- Pharyngitis or tonsillitis caused by S. pyogenes as an alternative to first-line therapy in individuals who cannot use first-line therapy.
- Prevention and treatment of acute bacterial exacerbations of chronic obstructive pulmonary disease due to H. influenzae, M. catarrhalis, or S. pneumoniae. The benefits of long-term prophylaxis must be weighed on a patient-by-patient basis against the risk of cardiovascular and other adverse effects.
- Trachoma due to C. trachomatis.
- Uncomplicated skin infections due to S. aureus, S. pyogenes, or S. agalactiae.
- Scrub typhus caused by Orientia tsutsugamushi.
Mechanism Of Action
Ximthro has relatively broad but shallow antibacterial activity. It inhibits some Gram-positive bacteria, some Gram-negative bacteria, and many atypical bacteria.
Ximthro prevents bacteria from growing by interfering with their . It binds to the 50S subunit of the bacterial , thus inhibiting of . Nucleic acid synthesis is not affected
Dosage
- Skin/Skin Structure (uncomplicated):
500 mg as a single dose on Day 1, followed by 250 mg once daily on Days 2-5 - Chronic Obstructive Pulmonary Disease:
500 mg as a single dose for 3 days OR
Alternatively, 500 mg as a single dose on Day 1, followed by 250 mg for 2-5 Days - Skin and Skin Structure Infection:
2gm in one single Dose
Gonococcal Urethritis and Cervicitis:
2gm in one single Dose - Acute Bacterial Sinusitis:
500 mg x 3 days